Ank3 loss in adult forebrain excitatory neurons disrupts behavior, neuronal activity, membrane proteome, and myelination

Proceedings of the National Academy of Sciences, Volume 123, Issue 35, September 2026. <br/>SignificanceThis study demonstrates that deletion ofAnk3in adult excitatory neurons is sufficient to induce behavioral abnormalities resembling bipolar disorder-like phenotypes. Ankyrin-G loss reduces neuronal activity and leads to a striking …



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