Plasmodium thiamine pyrophosphokinase is essential for sporozoite formation and activation of an antiplasmodial thiamine analogue

Proceedings of the National Academy of Sciences, Volume 123, Issue 35, September 2026. <br/>SignificanceMalaria parasites rely on thiamine pyrophosphate (TPP) for essential metabolic processes. This study shows that parasites that carry a mutation in thiamine pyrophosphokinase (TPK), the enzyme responsible for converting thiamine (vitamin B1) …



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