SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation



Proceedings of the National Academy of Sciences, Volume 123, Issue 35, September 2026. <br/>SignificanceEpstein–Barr virus (EBV) causes approximately 200,000 cancer deaths annually, yet therapeutic options remain limited by broad immunosuppression and variable efficacy. We demonstrate that SIRT2 deacylase modulators block EBV-driven B cell …



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